Inhibition of red cell membrane lipid peroxidation by sulphasalazine and 5-aminosalicylic acid.

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Inhibition of cell mediated cytotoxicity by sulphasalazine: effect of in vivo treatment with 5-aminosalicylic acid and sulphasalazine on in vitro natural killer cell activity.

Decreased cell mediated cytotoxicity occurs frequently in inflammatory bowel disease, particularly in patients with active disease. It is not clear, however, whether this decrease is caused by the disease or is a consequence of the medical treatment. In this study we evaluated the effect of in vivo treatment with 5-aminosalicylic acid and sulphasalazine on the in vitro natural killer cell activ...

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Antioxidant activity of 5-aminosalicylic acid against lipid peroxidation in the presence of vitamins C and E

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Lipid peroxidation in cell membrane phospholipids

duced by reactive oxygen species and/or free radicals leads to alterations in the membrane structure and functions of cells, and has been proposed as a major mechanism for the onset of several pathological events in vivo, including postischemicreperfusion injury, cancer, senile dementia and aging. A number of studies have shown that peroxidation of membrane lipids in cells gives rise to highly ...

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ژورنال

عنوان ژورنال: Gut

سال: 1991

ISSN: 0017-5749

DOI: 10.1136/gut.32.10.1156